{"id":7480,"date":"2020-09-01T22:55:17","date_gmt":"2020-09-01T19:55:17","guid":{"rendered":"https:\/\/krokosoc.goodbuild.eu\/inhibition-of-growth-of-promyelocytic-leukemia\/"},"modified":"2020-09-01T22:55:17","modified_gmt":"2020-09-01T19:55:17","slug":"inhibition-of-growth-of-promyelocytic-leukemia","status":"publish","type":"post","link":"https:\/\/safran.gr\/el\/inhibition-of-growth-of-promyelocytic-leukemia\/","title":{"rendered":"Inhibition of Growth of Promyelocytic Leukemia"},"content":{"rendered":"<h1>Inhibition of Growth and Induction of Differentiation of Promyelocytic Leukemia (HL-60) by Carotenoids From Crocus Sativus L<\/h1>\n<h3>Abstract<\/h3>\n<p>The effects of carotenoids of Crocus sativus L. (saffron) on cell proliferation and differentiation of HL-60 cells have been studied and compared with those of all-trans retinoic acid.<\/p>\n<p>Our results demonstrated that the doses inducing 50% inhibition of cell growth were 0.12 microM for all-trans retinoic acid (ATRA) and for carotenoids of saffron 0.8 microM for dimethylcrocetin (DMCRT), 2 microM for crocetin CRT and 2 microM for crocins (CRCs).<\/p>\n<p>At 5 microM, all these compounds induced differentiation of HL-60 cells, at 85% for ATRA, 70% for DMCRT, 50% for CRT and 48% for CRCs.<\/p>\n<p>In these experiments, leukemic cells were cultured for 5 days in the absence or in the presence of up to 5 microM ATRA or seminatural and natural carotenoids.<\/p>\n<p>Since retinoids have a potential application as chemopreventive agents in humans, their toxicity as an important limiting factor for their use in treatment should be extensively explored.<\/p>\n<p>The seminatural (DMCRT and CRT) and natural carotenoids (CRCs) of Crocus sativus L. are not provitamin A precursors and could therefore be less toxic than retinoids, even at high doses.<\/p>\n<h3>Read More<\/h3>\n<p><a href=\"https:\/\/www.researchgate.net\/profile\/Hamid_Morjani\/publication\/15351052_Inhibition_of_growth_and_induction_of_differentiation_of_promyelocytic_leukemia_HL-60_by_carotenoids_from_Crocus_sativus_L\/links\/0c960522e0e6ed75f8000000\/Inhibition-of-growth-and-induction-of-differentiation-of-promyelocytic-leukemia-HL-60-by-carotenoids-from-Crocus-sativus-L.pdf\">Inhibition of Growth and Induction of Differentiation of Promyelocytic Leukemia (HL-60) by Carotenoids From Crocus Sativus L<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Inhibition of Growth and Induction of Differentiation of Promyelocytic Leukemia (HL-60) by Carotenoids From Crocus Sativus L Abstract The effects of carotenoids of Crocus sativus L. (saffron) on cell proliferation and differentiation of HL-60 cells have been studied and compared with those of all-trans retinoic acid. Our results demonstrated that the doses inducing 50% inhibition 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