Xenopus Archives - Krokos Kozanis https://safran.gr/tag/xenopus/ Gold of the Greek Earth Wed, 17 Feb 2021 10:04:53 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.4 https://safran.gr/wp-content/uploads/2020/07/cropped-ΚΚ-Λογότυπο-Κρόκος-Κοζάνης-Θυρεός-2-32x32.jpg Xenopus Archives - Krokos Kozanis https://safran.gr/tag/xenopus/ 32 32 Evaluation of the Developmental Toxicity of Crocetin on Xenopus https://safran.gr/evaluation-of-the-developmental-toxicity-of-crocetin-on-xenopus/ Wed, 17 Jul 2002 13:01:44 +0000 https://krokoskozanis.goodsite.eu/?p=5539 Abstract Crocetin, a carotenoid isolated from the spice saffron, has been found to be effective in treating certain types of cancer treatable with all-trans retinoic acid (ATRA). ATRA, however, is a potent teratogen, and the possibility that crocetin may also be a teratogen becomes an important medical issue. The teratogenic potential of crocetin and ATRA […]

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Crocetin, a carotenoid isolated from the spice saffron, has been found to be effective in treating certain types of cancer treatable with all-trans retinoic acid (ATRA).

ATRA, however, is a potent teratogen, and the possibility that crocetin may also be a teratogen becomes an important medical issue.

The teratogenic potential of crocetin and ATRA were evaluated in frog (Xenopus) embryos.

The data show that crocetin is a teratogen, but far less potent than ATRA.

This suggests that crocetin may be a safer alternative to treat ATRA-sensitive cancers in women of childbearing age.

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Evaluation of the Developmental Toxicity of Crocetin on Xenopus

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